Understand the benefits of WELLBUTRIN XL®, its unique SmartCoat™ technology, and the differences between brand name and generic versions. Learn how to ensure you receive the brand name medication at the pharmacy. Wellbutrin XL (Bupropion Hydrochloride Extended-Release) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. Wellbutrin (bupropion) is used to treat major depressive disorder and seasonal affective disorder. Includes Wellbutrin side effects, interactions and indications. The FDA investigated these complaints and concluded that Budeprion XL is equivalent to Wellbutrin XL regarding bioavailability of bupropion and its main active metabolite hydroxybupropion. The official site for WELLBUTRIN XL® provides information for healthcare professionals on clinical experience in Major Depressive Disorder (MDD) and Seasonal Affective Disorder (SAD). Wellbutrin XL: side effects, dosage, interactions, FAQs, reviews. Used for: depression, major depressive disorder, seasonal affective disorder What is Wellbutrin XL? Wellbutrin XL is a prescription medicine used to treat adults with a certain type of depression called major depressive disorder. Wellbutrin XL contains the same active ingredient (bupropion hydrochloride) as Zyban. Zyban is used to help people stop smoking. Find patient medical information for Bupropion (Wellbutrin, Zyban, and others) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings Bupropion is used to treat major depressive disorder (MDD) and to prevent seasonal affective disorder (SAD), which is sometimes called autumn-winter seasonal depression. It is also used as part of a support program to help people stop smoking. Bupropion is sold under different brand names. Wellbutrin XL ® (bupropion hydrochloride extended-release) tablets is indicated for the treatment of major depressive disorder (MDD), as defined by the Diagnostic and Statistical Manual (DSM).